VanScott

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Michael R. Van Scott, Ph.D.

Professor
Department of Physiology

Brody		6N-84
Phone		(252) 744-3654
FAX		(252) 744-3460
vanscottmi@.ecu.edu Mailing Address: East Carolina University Brody School of Medicine Department of Physiology 600 Moye Blvd. Brody 6N-82 Greenville, NC 27834

Research Interests

Dr. Van Scott pursues three related multidisciplinary research projects. In collaboration with Dr. Wardle and scientists in pharmaceutical and biotechnology industries, he conducts preclinical testing of novel therapeutics for the treatment of asthma. The group pursues studies into the mechanisms underlying asthma, ways to improve the predictive value of asthma models, and assessment of the therapeutic potential of emerging drug candidates. The second project is conducted in conjunction with Dr. Jeff Fedan at the National Institute of Occupational Safety and Health and students at West Virginia University. Studies are performed at the Appalachian Laboratory for Occupational Safety and Health in Morgantown, WV, to better understand control of airway smooth muscle contraction and airway hyper-reactivity. The group is particularly interested in how changes in osmolarity within the airway surface liquid, as observed in exercise-induced asthma, affect release of relaxing factors from the epithelium lining the respiratory tract airway smooth muscle contractility. The third project involves collaboration with scientists at the US EPA and Drs. Wingard, Lust, and Cascio at ECU to investigate the impact of allergens and particulate air pollution on cardiovascular function. Early observations revealed that airborne allergens and particulate pollution alter vascular reactivity and increase the severity of adverse cardiac events, such as myocardial infarction. The group is currently pursuing investigations into the transduction processes by which particulate exposure alters cardiovascular function.

Education / Employment

Professor (2000-present)
Associate Professor (1993-2000)
Assistant Professor (1990-1993)
Department of Physiology
Brody School of Medicine at East Carolina University
Greenville, NC

Research Assistant Professor (1986-1990)
Department of Medicine
Division of Pulmonary Diseases
University of North Carolina at Chapel Hill, NC

Post-doctoral Fellowship (1984-1986)
Division of Pulmonary Diseases
Department of Medicine
University of North Carolina, Chapel Hill, NC

Doctor of Philosophy in Physiology (1984)
West Virginia University
Morgantown, WV

Research training (1982-1984)
National Institute of Occupational Safety and Health
Appalachian Laboratory for Occupational Safety and Health
Morgantown, WV

Bachelor of Science, Biology (1981)
Cornell University
Ithaca, NY

Medical Corpsman (1978-1979)
82nd Airborne Division
United States Army, Fort Bragg, NC

Photochemical technician (1977-1978)
Eastman Kodak Company
Rochester, NY

Patents

Pending: Device to Measure Muscle Contractile/Relaxant and Epithelial Bioelectric Responses of Perfused, Intact Airways In Vitro, CDC Tech ID No. I-004-05, Co-inventor.

Selected Publications

1. J.S. Fedan, J.A. Dowdy, R.A. Johnston, and M.R. Van Scott. Hyperosmolar solution effects in guinea-pig isolated, perfused trachea. I. Release of epithelium-derived relaxing factor by relative changes in osmolarity. J. Pharmacol. Exp. Ther. 308(1):10-18, 2004.

2. Wu, D. X.-Y., R. A. Johnston, A. Rengasamy,M. R. Van Scott, and J S. Fedan. Hyperosmolar solution effects in guinea-pig isolated, perfused trachea. II. Effect of osmolarity on epithelial bioelectric properties. J. Pharmacol. Exp. Ther. 308(1):19-29, 2004.

3. Fedan, J S., J. A. Dowdy, M. R. Van Scott, D. X.-Y. Wu, and R. A. Johnston. Hyperosmolar solution effects in airways. III. Studies on the identity of epithelium-derived relaxing factor in guinea-pig isolated, perfused trachea using pharmacological agents. J. Pharmacol. Exp. Ther. 308(1):30-36, 2004.

4. Johnston, R. A., M. R. Van Scott, C. Kommineni, L. L. Millecchia, J. Dortch-Carnes, and Jeffrey S. Fedan. Hyperosmolar solution effects in guinea-pig airways. IV.Lipopolysaccharide-induced alterations in airway reactivity to methacholine and epithelium-derived relaxing factor. J. Pharmacol. Exp. Ther. 308(1):37-46, 2004

5. Van Scott, M.R., J. L. Hooker, D. Ehrmann, Y. Shibata, C. Kukoly, K. Salleng, A. Sandrasagra, and J. Nyce. Dust mite-induced asthma in cynomolgus monkeys. J. Applied Physiol. 96(4):1433-44, 2004 (10.1152/japplphysiol.01128.2003).

6. Hazarika, S., M.R. Van Scott, and R.M. Lust. Myocardial ischemia-reperfusion injury is enhanced in a model of systemic allergy and asthma. Am J Physiol Heart Circ Physiol. 286(5):H1720-H1725, 2004 (10.1152/ajpheart.01064.2003).

7. Van Scott, M.R., D. Aycock, E. Cozzi, K. Salleng, and H.W. Stallings. Separation of bronchoconstriction from increased ventilatory drive in a nonhuman primate model of chronic allergic asthma. J. Applied Physiol. 99(6):2080-6, 2005. (10.1152/japplphysiol.00537.2005;http://jap.physiology.org/cgi/reprint/00537.2005v1)

8. Cozzi E., S. Hazarika , H.W. Stallings III, W.E. Cascio, R.B. Devlin, R.M. Lust, C.J. Wingard, M.R. Van Scott. Ultrafine particulate matter exposure augments ischemia reperfusion injury in mice. Am J Physiol Heart Circ Physiol. 291(2):H894-903, 2006. (http://ajpheart.physiology.org/cgi/reprint/01362.2005v1).

9. Fedan, J.S., D.X-Y Wu, and M.R. Van Scott, and. Altered Ion transport and responsiveness to methacholine and hyperosmolarity in air-liquid interface-cultured guinea-pig tracheal epithelium. Journal of Pharmacology and Experimental Therapeutics 55(2):135-43, 2007.

10. Hazarika, S., M.R. Van Scott, and R.M. Lust. Severity of myocardial injury following ischemia-reperfusion is increased in a mouse model of allergic asthma. Am J Physiol Heart Circ Physiol Am J Physiol Heart Circ Physiol. 292(1):H572-9, 2007.

11. Murashov, A.K., V. Chintalgattu, R.R. Islamov, T.E. Lever, E.S. Pak, P.L. Sierpinski, L.C. Katwa, and M.R. Van Scott, RNAi Pathway is Functional in Peripheral Nerve Axons, FASEB J. 21(3):656-70, 2007.

12. Cozzi, E., C.J. Wingard, W.E. Cascio, R.B. Devlin, J.J. Miles, R.M. Lust, M.R. Van Scott, and R.A. Henriksen. Exposure to ultrafine particulate matter increases thrombogenic potential. Translational Research 149(6):324-32, 2007

		Physiology Research Program summary
		Community of Science listing

PubMed Publications

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